NCT07916064 Effect of Ketamine on Optic Nerve Sheath Diameter During Procedural Analgesia
| NCT ID | NCT07916064 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ankara Etlik City Hospital |
| Condition | Procedural Pain |
| Study Type | OBSERVATIONAL |
| Enrollment | 160 participants |
| Start Date | 2025-12-15 |
| Primary Completion | 2026-12-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 160 participants in total. It began in 2025-12-15 with a primary completion date of 2026-12-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to learn whether ketamine given for procedural analgesia changes intracranial pressure in adult emergency department patients. Intracranial pressure is assessed non-invasively by measuring optic nerve sheath diameter (ONSD) with bedside ultrasonography. The main questions it aims to answer are: * Does ONSD change after ketamine administration compared with the measurement taken before ketamine? * Does the change in ONSD differ between patients receiving 0.5 mg/kg and 1 mg/kg ketamine? Participants who receive intravenous ketamine as part of their routine emergency care will have ONSD, vital signs, and pain scores recorded before ketamine administration and at 2, 5, 15, and 30 minutes after administration.
Eligibility Criteria
Inclusion Criteria: * Age 18 years or older * Hemodynamically stable * Receiving intravenous ketamine for procedural analgesia for any clinical indication * Written and verbal informed consent Exclusion Criteria: * Pregnancy or suspected pregnancy * History of moderate or severe head trauma * History of cerebrovascular disease * Intracranial mass * Previous intracranial surgery * Signs of increased intracranial pressure * Chronic obstructive pulmonary disease * Hypercapnia * Porphyria * Liver failure * Chronic kidney disease * Cerebral palsy * Multiple sclerosis * Use of antidepressant medication * Optic neuritis * Globe rupture * Glaucoma * Use of an agent other than ketamine for procedural analgesia * Known allergy or intolerance to ketamine * Disorientation, inability to cooperate, or inability to communicate
Frequently Asked Questions
Who can join the NCT07916064 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Procedural Pain. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07916064 currently recruiting?
Yes, NCT07916064 is actively recruiting participants. Visit ClinicalTrials.gov or contact Ankara Etlik City Hospital to inquire about joining.
Where is the NCT07916064 trial being conducted?
This trial is being conducted at Ankara, Turkey (Türkiye).
Who is sponsoring the NCT07916064 clinical trial?
NCT07916064 is sponsored by Ankara Etlik City Hospital. The trial plans to enroll 160 participants.