NCT07318298 Effect of Injectable Hyaluronic Acid (HYADENT BG (HA)) on Bone Healing in Extraction Sockets
| NCT ID | NCT07318298 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Jordan University of Science and Technology |
| Condition | The Application of Hyaluronic Acid on Teeth Bone Healing. Hyaluronic Acid Which is Widely Used in Medicine for Joint, Eye Care, Wound Healing |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2024-08-01 |
| Primary Completion | 2026-02-26 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2024-08-01 with a primary completion date of 2026-02-26.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Complications such as postoperative pain and delayed socket healing are relatively common following surgical extraction of mandibular third molars. Various biomaterials have been investigated to enhance wound healing and reduce postoperative morbidity. Hyaluronic acid (HA) has demonstrated anti-inflammatory and regenerative properties that may improve both soft and hard tissue healing. The aim of this study is to evaluate the effect of topical hyaluronic acid on postoperative pain and alveolar socket bone healing following surgical extraction of mandibular third molars. A prospective, randomized, controlled clinical trial with a split-mouth design will be conducted. Twenty patients requiring bilateral mandibular third molar surgical extraction will be enrolled. In each patient, one extraction socket will receive hyaluronic acid combined with a collagen sponge, while the contralateral socket will receive a collagen sponge alone, according to random allocation. Postoperative pain will be assessed using a visual analogue scale, and socket healing will be evaluated radiographically and histologically.
Eligibility Criteria
Inclusion Criteria: Male and female participants aged 18 to 35 years Presence of bilateral impacted mandibular third molars classified as Pell and Gregory Class II, Position B Classified as American Society of Anesthesiologists (ASA) Physical Status I Absence of active local infection at the surgical site (e.g., no swelling, trismus, hyperthermia) Ability to maintain adequate oral hygiene Ability to understand and provide written informed consent Ability to read and understand Arabic or English Willingness to comply with study procedures and follow-up visits Exclusion Criteria: History of systemic diseases such as diabetes mellitus, hypertension, gastric ulcer, or other significant medical conditions Presence of severe or chronic illness requiring frequent hospitalization Pregnant or breastfeeding individuals History of cognitive or motor impairment that may interfere with study participation Use of anti-inflammatory or analgesic medications within two weeks before surgery Known allergy or hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) Current smoker Use of anticoagulant therapy Any condition that, in the investigator's judgment, may interfere with healing or study outcomes
Contact & Investigator
Rola Habashneh, Professor
STUDY CHAIR
Jordan University of Science and Technology
Frequently Asked Questions
Who can join the NCT07318298 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 35 Years, studying The Application of Hyaluronic Acid on Teeth Bone Healing. Hyaluronic Acid Which is Widely Used in Medicine for Joint, Eye Care, Wound Healing. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07318298 currently recruiting?
Yes, NCT07318298 is actively recruiting participants. Contact the research team at zztamimi@just.edu.jo for enrollment information.
Where is the NCT07318298 trial being conducted?
This trial is being conducted at Irbid, Jordan.
Who is sponsoring the NCT07318298 clinical trial?
NCT07318298 is sponsored by Jordan University of Science and Technology. The principal investigator is Rola Habashneh, Professor at Jordan University of Science and Technology. The trial plans to enroll 20 participants.