NCT07638176 Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
| NCT ID | NCT07638176 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Samsung Medical Center |
| Condition | Pulmonary Disease (COPD), Chronic Obstructive |
| Study Type | INTERVENTIONAL |
| Enrollment | 48 participants |
| Start Date | 2026-08-01 |
| Primary Completion | 2027-05-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 48 participants in total. It began in 2026-08-01 with a primary completion date of 2027-05-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.
Eligibility Criteria
Inclusion Criteria: * American Society of Anesthesiologists Physical Status I - III * The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2 * Lung resection surgery requiring one-lung ventilation for over 60 minutes * Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr) * Patient who is diagnosed with intrinsic PEEP during one-lung ventilation Exclusion Criteria: * Large bullae * Emergency surgery * Mechanical ventilation before surgery * Hemodynamic instability before surgery * Surgery requiring cardiopulmonary bypass * Pregnancy, breastfeeding patient * Patient's refusal to participate * No intrinsic PEEP during one-lung ventilation
Contact & Investigator
Hyun Joo Ahn, MD, PhD
PRINCIPAL INVESTIGATOR
Samsung Medical Center
Frequently Asked Questions
Who can join the NCT07638176 clinical trial?
This trial is open to participants of all sexes, aged 19 Years or older, up to 100 Years, studying Pulmonary Disease (COPD), Chronic Obstructive. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07638176 currently recruiting?
Yes, NCT07638176 is actively recruiting participants. Contact the research team at hyunjooahn@skku.edu for enrollment information.
Where is the NCT07638176 trial being conducted?
This trial is being conducted at Seoul, South Korea.
Who is sponsoring the NCT07638176 clinical trial?
NCT07638176 is sponsored by Samsung Medical Center. The principal investigator is Hyun Joo Ahn, MD, PhD at Samsung Medical Center. The trial plans to enroll 48 participants.
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