NCT07228182 Effect of High-Intensity Transcranial Alternating Current Stimulation on Gambling Disorder: A Randomized Controlled Trial
| NCT ID | NCT07228182 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Shanghai Mental Health Center |
| Condition | Gambling Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2026-06-01 |
| Primary Completion | 2026-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2026-06-01 with a primary completion date of 2026-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The investigators assume that High-intensity transcranial Alternating Current Stimulation (HI-tACS) could improve gambling disorder patients' executive-control function by modulating abnormal neural activity, particularly gamma-band oscillations, which are closely associated with executive-control deficits. This study intends to validate the effect of HI-tACS treatment, which has been discovered in the previous pilot study. A three-month follow-up assessment will be conducted to test the changes in executive-control function and its underlying mechanism.
Eligibility Criteria
Inclusion Criteria: * Aged 18-60, male or female, with 9 or more years of education, and able to complete questionnaire evaluation and behavioral tests; * Meet DSM-5 (Diagnostic and Statistical Manual of mental disorders，DSM) diagnostic criteria for gambling disorder; * Have gambled for at least one year (at least once a week); * Normal vision and hearing, or within the normal range after correction; * Agree to cooperate in the follow-up evaluation; * No metal implantation in the head, no history of nerve problems or head injury, and no skin sensitivity. Exclusion Criteria: * Have severe cognitive impairment, such as a history of head trauma, -cerebrovascular disease, epilepsy, etc.; * Have used drugs promoting cognitive function in the last 6 months; * Have impaired intelligence (Intelligence Quotient\<70); * Abuse or dependence of psychoactive substances (except nicotine) in the last 5 years.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07228182 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Gambling Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07228182 currently recruiting?
Yes, NCT07228182 is actively recruiting participants. Contact the research team at dujiangdou@163.com for enrollment information.
Where is the NCT07228182 trial being conducted?
This trial is being conducted at Shanghai, China.
Who is sponsoring the NCT07228182 clinical trial?
NCT07228182 is sponsored by Shanghai Mental Health Center. The trial plans to enroll 60 participants.