NCT06230614 Effect of Diluent Volume on Colistin Inhalation Therapy
| NCT ID | NCT06230614 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Fu Jen Catholic University |
| Condition | Inhalation Pneumonia |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2024-03-10 |
| Primary Completion | 2026-07-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2024-03-10 with a primary completion date of 2026-07-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of this study is to investigate the impact of different diluent volumes for the same dosage of colistin in mechanically ventilated respiratory patients receiving colistin inhalation therapy. The study aims to determine whether the diluent volume has an effect on clinical outcomes, including ICU length of stay, total hospitalization duration, duration of respiratory support within 28 days, mortality rates within 28 days and 90 days, as well as analyze the pharmacokinetic profile of colistin in blood and bronchoalveolar lavage fluid. Additionally, the study will evaluate the incidence of nebulizer malfunctions and blockages. The findings of this research will help identify the optimal diluent volume for colistin inhalation therapy in clinical practice.
Eligibility Criteria
Inclusion Criteria: * Admitted to the Intensive Care Unit. * Age greater than 18 years and using a ventilator due to acute respiratory failure. * Requires inhalation colistin treatment as determined by the disease. * Sign the written informed consent form. Exclusion Criteria: * Renal failure requiring renal dialysis. * Receiving both inhaled colistin and intravenous colistin treatments.
Contact & Investigator
Ke-Yun Chao, PhD
PRINCIPAL INVESTIGATOR
Fu Jen Catholic University Hospital
Frequently Asked Questions
Who can join the NCT06230614 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 100 Years, studying Inhalation Pneumonia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06230614 currently recruiting?
Yes, NCT06230614 is actively recruiting participants. Contact the research team at C00152@mail.fjuh.fju.edu.tw for enrollment information.
Where is the NCT06230614 trial being conducted?
This trial is being conducted at New Taipei City, Taiwan.
Who is sponsoring the NCT06230614 clinical trial?
NCT06230614 is sponsored by Fu Jen Catholic University. The principal investigator is Ke-Yun Chao, PhD at Fu Jen Catholic University Hospital. The trial plans to enroll 60 participants.