Effect of Diluent Volume on Colistin Inhalation Therapy
Trial Parameters
Brief Summary
The aim of this study is to investigate the impact of different diluent volumes for the same dosage of colistin in mechanically ventilated respiratory patients receiving colistin inhalation therapy. The study aims to determine whether the diluent volume has an effect on clinical outcomes, including ICU length of stay, total hospitalization duration, duration of respiratory support within 28 days, mortality rates within 28 days and 90 days, as well as analyze the pharmacokinetic profile of colistin in blood and bronchoalveolar lavage fluid. Additionally, the study will evaluate the incidence of nebulizer malfunctions and blockages. The findings of this research will help identify the optimal diluent volume for colistin inhalation therapy in clinical practice.
Eligibility Criteria
Inclusion Criteria: * Admitted to the Intensive Care Unit. * Age greater than 18 years and using a ventilator due to acute respiratory failure. * Requires inhalation colistin treatment as determined by the disease. * Sign the written informed consent form. Exclusion Criteria: * Renal failure requiring renal dialysis. * Receiving both inhaled colistin and intravenous colistin treatments.