NCT06889961 Effect of Daily Mixed Spice Consumption on Memory Function
| NCT ID | NCT06889961 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, Los Angeles |
| Condition | Memory |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2025-02-21 |
| Primary Completion | 2027-02-21 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2025-02-21 with a primary completion date of 2027-02-21.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aging process entails a multitude of structural and functional alterations within the brain, culminating in a gradual and progressive decline in cognitive function. Recent research has indicated that various spices may hold the key to enhancing brain health and combating the effects of aging on cognitive abilities. The hypothesis is that a mixture of spices, acknowledged for their reported memory protection potential, may yield a more potent beneficial effect on memory function than a single spice. The spice mixture will be used at culinary dose, and therefore side effects are anticipated. In this study, the effects of spice mixture will be evaluated, as well as their anti-oxidant, and anti-inflammatory properties. The proposed pilot study will include 50 adults (ages 50-80), exhibiting typical age-related mild cognitive decline, excluding dementia or major neurocognitive disorders. They will be randomized 1:1 assigned into a daily intake of either 4.00 g spice mixture capsules or 4.00 g maltodextrin capsules over 3 months, and explore the sustainable effect over 3 additional months. The changes in symptoms of cognition, fatigue, and mood symptoms of the spice group vs. placebo group will be compared. The outcome of the investigation of the effects of mixed spice consumption will provide important novel information on dietary recommendation of spice to preserve cognitive function in aging population.
Eligibility Criteria
Inclusion Criteria: 1. Participants are required to have clinical histories consistent with normal aging or mild cognitive impairment (MCI). 2. Age 50 to 80 years. 3. Adequate visual acuity and hearing to allow neuropsychological testing. 4. Screening laboratory tests without significant abnormalities that might interfere with the study. \- Exclusion Criteria: 1. Diagnosis of probable Alzheimer's disease or any other dementia (e.g. vascular, Lewy body, frontotemporal) 2. Evidence of other neurological or physical illness that can produce cognitive deterioration. Determination of dementia will be based on the clinical evaluation including assessment of functional abilities, and cognitive screening (using the Mini Mental State Examination 3. Evidence of Parkinson's disease as determined by the motor examination (items 18-31) of the Unified Parkinson's Disease Rating Scale \[38\]. 4. Uncontrolled hypertension (systolic blood pressure (BP) \> 170 or diastolic BP \> 100). 5. Consume spices regularly \> 5g day 6. Allergy or sensitivity to spices. Subjects will be excluded if there is a prior history of such sensitivity. Since these foods are commonly eaten and allergies are rare, subjects should be aware of this sensitivity prior to entering the study. To determine this, a positive history of spices ingestion without incident will be requested. In addition, any subject with a history of allergy or anaphylaxis of any kind will be excluded. 7. Current diagnosis of any major psychiatric disorder according to the DSM-IV TR criteria (APA, 2000). 8. Current diagnosis or alcoholism or substance addiction. 9. Eating a high fiber/polyphenol diet or taking any medication or dietary supplement which interfere with the absorption of polyphenols. 10. Frequently using prebiotics, probiotics, yogurt, and/or any fiber supplements
Contact & Investigator
Zhaoping Li
PRINCIPAL INVESTIGATOR
University of California, Los Angeles
Frequently Asked Questions
Who can join the NCT06889961 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 80 Years, studying Memory. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06889961 currently recruiting?
Yes, NCT06889961 is actively recruiting participants. Contact the research team at uclanutrition@gmail.com for enrollment information.
Where is the NCT06889961 trial being conducted?
This trial is being conducted at Los Angeles, United States.
Who is sponsoring the NCT06889961 clinical trial?
NCT06889961 is sponsored by University of California, Los Angeles. The principal investigator is Zhaoping Li at University of California, Los Angeles. The trial plans to enroll 50 participants.