NCT07256691 Effect of Calcium-Based Bioceramic Sealer and Resin-Based Sealer on Postoperative Pain
| NCT ID | NCT07256691 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Fatima Memorial Hospital |
| Condition | Asymptomatic Apical Periodontitis |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-12-01 |
| Primary Completion | 2026-02-28 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-12-01 with a primary completion date of 2026-02-28.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to compare the effect of calcium-based bioceramic sealer and resin-based sealer on postoperative pain in adult patients with asymptomatic apical periodontitis undergoing root canal treatment. Asymptomatic apical periodontitis is a condition where the tissue around the tip of the tooth root is inflamed or shows a lesion on X-ray, but the patient does not experience pain. A total of 60 patients will be randomly assigned to receive root canal treatment with either the bioceramic sealer (Group A) or the resin-based sealer (Group B). Pain after treatment will be measured using a 0-10 Numeric Pain Rating Scale at 4, 24, and 48 hours post-treatment. The highest pain score reported will determine whether the treatment is considered a success (no or mild/moderate pain) or failure (severe pain). The results of this study will provide evidence on which sealer is associated with less postoperative pain, helping clinicians make informed decisions about root canal filling materials.
Eligibility Criteria
Inclusion Criteria:Age 18-55 years. * Both genders. * Teeth diagnosed with asymptomatic apical periodontitis. * Teeth are asymptomatic (no pain on percussion or palpation). * Non-vital pulp (no response on Electric Pulp Testing). * Teeth with fully formed apices. * Teeth with Periapical Index (PAI) scores 2-4 on radiographs. Exclusion Criteria: * Medically compromised patients (e.g., those with immunosuppressive or systemic diseases, or on medications that may affect healing). * Patients who refuse to participate or are unable to communicate their symptoms (e.g., due to psychological disorders). * Teeth where full working length cannot be reached. * Periodontally compromised teeth (probing depth \>4 mm). * Complications during treatment (e.g., separation of a file, ledging). * Overfilling (filling beyond the radiographic apex) or short filling (\>2 mm from the radiographic apex).
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07256691 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 55 Years, studying Asymptomatic Apical Periodontitis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07256691 currently recruiting?
Yes, NCT07256691 is actively recruiting participants. Contact the research team at shehryar_jadun@yahoo.com for enrollment information.
Where is the NCT07256691 trial being conducted?
This trial is being conducted at Lahore, Pakistan.
Who is sponsoring the NCT07256691 clinical trial?
NCT07256691 is sponsored by Fatima Memorial Hospital. The trial plans to enroll 60 participants.