NCT02299921 Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure
| NCT ID | NCT02299921 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Colorado, Denver |
| Condition | Infection |
| Study Type | OBSERVATIONAL |
| Enrollment | 300 participants |
| Start Date | 2014-11 |
| Primary Completion | 2029-04-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 300 participants in total. It began in 2014-11 with a primary completion date of 2029-04-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study plans to learn more about people who are sick in the hospital with a lung infection, or respiratory failure. Respiratory failure, or severe lung failure, is a life-threatening disease. When it happens, the lungs have trouble carrying out their normal function of getting oxygen into the blood, and removing carbon dioxide from the body. Investigators are conducting this study to see what drinking too much alcohol, using tobacco products, or using drugs (both legal and illegal) may do to lung infections and respiratory failure. Subjects are asked to be in this research study because they are thought to have a lung infection and may also have respiratory failure. Alcohol, tobacco, and drug use have been linked to lung infections, respiratory failure, and even death, but the reasons for this aren't known. People who use unhealthy amounts of alcohol, tobacco, and or drugs may be more at risk for lung infections, and for severe complications due to lung infection. Subject participation is important whether or not you use alcohol and or drugs.
Eligibility Criteria
Inclusion criteria: * Specific Aim 1: Adult medical ICU patients admitted to the University of Colorado Hospital for a primary respiratory problem, and who are expected to require ICU care ≥48 hrs * Specific Aim 2: (1) Adult medical ICU patients with respiratory failure (due to underlying lung pathology) and who require endotracheal intubation and mechanical ventilation. (2) Adult medical and other ICU patients with respiratory failure, not related to a lung condition, and who require endotracheal intubation and mechanical ventilation. (3) Adult ICU patients previously admitted to the University of Colorado Hospital for a primary respiratory problem, and who required care ≥48 hrs. Exclusion criteria, Specific Aim 1 and 2: * Patients who are expected to require ICU care \<48 hrs * Patients admitted to the ICU who are not ICU status (being housed for space issues) * Patient is unlikely to survive 48 hours * Patient is on comfort care (hospice measures) * Patients less than 18 or greater than 90 years of age * Patient is a prisoner * ICU attending declines enrollment of patient * Patients who are pregnant * Patients who have significant anemia, defined as Hgb\<8% or Hct\<24%, or who have evidence of active bleeding. For bronchoscopy portion of Specific Aim 2. * Patients who are on either a fraction of inspired oxygen inspired oxygen fraction (FiO2)\>80% or positive end expiratory pressure (PEEP) \>10 cm H20 * Patients with platelets less than 30,000(chronically) * Patients who are expected to undergo a spontaneous breathing trial within the next 4 hours * Patients with an order or plan to extubate in the next 4 hours * Patients who have an endotracheal tube (ETT) \<7.5 F * Patients who are currently dangerously agitated * Pregnant women Exclusion criteria (outpatients ONLY for SA2 (3)): 1. Patients who required ICU care \<48 hrs 2. Patients less than 18 or greater than 90 years of age 3. Patient is a prisoner 4. Patients who are pregnant 5. Residency \> 40 miles from UCH clinics 6. non-English or non-Spanish speaking 7. Inability to perform study procedures (i.e. physical disability) 8. unable to perform pulmonary function testing 9. diagnosis of chronic pulmonary disease (e.g. COPD) 10. diagnosis of chronic neurodegenerative disease or severe dementia 11. history of anoxic or traumatic brain injury 12. prior ICU hospitalization at a non-UCH facility.
Contact & Investigator
Ellen L Burnham, MD
PRINCIPAL INVESTIGATOR
University of Colorado, Denver
Frequently Asked Questions
Who can join the NCT02299921 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 90 Years, studying Infection. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT02299921 currently recruiting?
Yes, NCT02299921 is actively recruiting participants. Contact the research team at ellen.burnham@ucdenver.edu for enrollment information.
Where is the NCT02299921 trial being conducted?
This trial is being conducted at Aurora, United States.
Who is sponsoring the NCT02299921 clinical trial?
NCT02299921 is sponsored by University of Colorado, Denver. The principal investigator is Ellen L Burnham, MD at University of Colorado, Denver. The trial plans to enroll 300 participants.