Effect of Acupuncture on IVF Pregnancy Outcomes for Women With RIF
Trial Parameters
Brief Summary
The randomized, placebo-controlled multicenter trial is conducted in five centers in China. After screening and obtaining the signed informed consent , the participants are randomly divided into three groups: acupuncture group (Acu.+IVF），sham acupuncture group（Sham Acu. +IVF），and the control group (only IVF).
Eligibility Criteria
Inclusion Criteria: 1. Married women aged 25-40; 2. Repeated implantation failure for unknown reasons (experienced 2 or more embryo transfers of good-quality embryos without achieving clinical pregnancy); 3. Transplantable Day 3 high-quality frozen embryos or frozen blastocysts (≥3BB); 4. Estrogen and progesterone replacement therapy (HRT), endometrial thickness ≥7mm on the day of endometrial transformation. Exclusion Criteria: Patients who met any of the following conditions were not included. 1. Those who prepare for PGD; 2. Recipients of egg donors; 3. Chromosomal abnormalities in both or one of the couples (excluding chromosome polymorphism); 4. patients with implantation failure due to known embryonic factors; 5. Uterine lesions that may affect implantation (including uterine malformation, \>4cm intramural fibroids，submucosal fibroids, adenomyosis, uterine tuberculosis, intrauterine adhesions, etc. 6. Repeated spontaneous abortion (2 or more fetal loss before 28 weeks of gestation