NCT07642765 EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery
| NCT ID | NCT07642765 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Konya City Hospital |
| Condition | Hypotension on Induction |
| Study Type | OBSERVATIONAL |
| Enrollment | 160 participants |
| Start Date | 2026-07-01 |
| Primary Completion | 2027-02-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 160 participants in total. It began in 2026-07-01 with a primary completion date of 2027-02-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Post-induction hypotension (PIH) is a common and clinically significant hemodynamic complication following general anesthesia induction. Frail patients are particularly vulnerable due to impaired vascular reactivity and endothelial dysfunction. The Endothelial Activation and Stress Index (EASIX), calculated from routine laboratory parameters (LDH, creatinine, and platelet count), may serve as a preoperative biomarker to identify patients at risk for PIH. This prospective observational cohort study aims to evaluate the association between preoperative EASIX score and the occurrence of post-induction hypotension in frail patients undergoing elective non-cardiac surgery under general anesthesia. A total of 160 patients with a Clinical Frailty Scale (CFS) score of 4 or above will be enrolled. Mean arterial pressure will be measured every 2 minutes for the first 15 minutes after induction. PIH is defined as MAP below 65 mmHg and/or a decrease of 20% or more from baseline.
Eligibility Criteria
Inclusion Criteria: * Age 18 years or older * Scheduled for elective non-cardiac surgery under general anesthesia * Clinical Frailty Scale (CFS) score of 4 or above * Available routine preoperative laboratory values (LDH, creatinine, platelet count) within 24 hours before surgery Exclusion Criteria: * Cardiac surgery * Emergency surgery * Preoperative vasopressor infusion * Severe hematological disease * Missing laboratory data required for EASIX calculation
Contact & Investigator
Mustafa Aydemir, MD
PRINCIPAL INVESTIGATOR
Konya City Hospital
Frequently Asked Questions
Who can join the NCT07642765 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Hypotension on Induction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07642765 currently recruiting?
Yes, NCT07642765 is actively recruiting participants. Contact the research team at drmustafaaydemir02@gmail.com for enrollment information.
Where is the NCT07642765 trial being conducted?
This trial is being conducted at Konya, Turkey (Türkiye).
Who is sponsoring the NCT07642765 clinical trial?
NCT07642765 is sponsored by Konya City Hospital. The principal investigator is Mustafa Aydemir, MD at Konya City Hospital. The trial plans to enroll 160 participants.