NCT07799636 Early Warning and Stratified Diagnosis of Postoperative Respiratory Failure Based on Ventilator Waveform Image Features
| NCT ID | NCT07799636 |
| Status | Recruiting |
| Phase | — |
| Sponsor | West China Hospital |
| Condition | Postoperative Respiratory Failure |
| Study Type | OBSERVATIONAL |
| Enrollment | 250 participants |
| Start Date | 2025-12-29 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 250 participants in total. It began in 2025-12-29 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
I. Study Background Postoperative respiratory failure (PRF) is a common and serious complication following major surgery, significantly increasing the rates of ICU admission and mortality. Traditional early warning methods primarily rely on blood gas analysis and vital sign monitoring, which are often delayed and may fail to identify early pathological changes in a timely manner. In recent years, ventilator waveforms, as dynamic information that directly reflects respiratory mechanics and airway conditions, have gradually attracted increasing attention in the optimization of respiratory support. International studies have suggested that analysis of ventilator waveform features may help identify patient-ventilator asynchrony, excessive spontaneous respiratory effort, ventilation-perfusion mismatch, and ventilator-related complications. In China, although a limited number of studies have explored this area, most have focused on individual parameters and lack systematic and prospective clinical validation. Therefore, this study aims to establish a large prospective cohort and integrate image feature extraction with stratified diagnostic modeling to achieve early warning and risk stratification of postoperative respiratory failure. This study is expected not only to address the current gap in this field in China but also to provide evidence-based support for precision respiratory management and improved clinical outcomes.
Eligibility Criteria
Inclusion Criteria: * Age ≥18 years; * Patients receiving mechanical ventilation after surgery and transferred directly to the ICU; * Patients expected to require or actually requiring mechanical ventilation for more than 24 hours after surgery; * Patients or their legally authorized representatives providing written informed consent. Exclusion Criteria: * Respiratory failure occurring before surgery; * Severe pulmonary disease diagnosed before surgery, including but not limited to severe chronic obstructive pulmonary disease (COPD; GOLD stage 3-4), severe interstitial lung disease (PaO₂/FiO₂ \<300 mmHg), active pneumonia, and severe pulmonary hypertension; * Preoperative mechanical ventilation for \>48 hours; * A decision made immediately after surgery to withhold or withdraw active treatment, including invasive mechanical ventilation; * Expected survival of less than 48 hours; * Inability to connect to or record the required ventilator waveform data and/or electronic medical record data; * Other severe underlying diseases, including but not limited to end-stage liver disease, dialysis-dependent renal failure, and advanced malignancy with a short expected survival.
Contact & Investigator
Chi Zhang, Dr.
PRINCIPAL INVESTIGATOR
West China Hospital
Frequently Asked Questions
Who can join the NCT07799636 clinical trial?
This trial is open to participants of all sexes, studying Postoperative Respiratory Failure. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07799636 currently recruiting?
Yes, NCT07799636 is actively recruiting participants. Contact the research team at zhangchifujian@qq.com for enrollment information.
Where is the NCT07799636 trial being conducted?
This trial is being conducted at Chengdu, China.
Who is sponsoring the NCT07799636 clinical trial?
NCT07799636 is sponsored by West China Hospital. The principal investigator is Chi Zhang, Dr. at West China Hospital. The trial plans to enroll 250 participants.