NCT04221737 Early Use of Airway Pressure Release Ventilation (APRV) in ARDS
| NCT ID | NCT04221737 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Hospital Civil de Guadalajara |
| Condition | Acute Respiratory Distress Syndrome |
| Study Type | INTERVENTIONAL |
| Enrollment | 150 participants |
| Start Date | 2017-07-15 |
| Primary Completion | 2025-11 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 150 participants in total. It began in 2017-07-15 with a primary completion date of 2025-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Airway pressure release ventilation (APRV) is a time-cycled, pressure controlled, intermittent mandatory ventilation mode with extreme inverse I:E ratios. Currently it is considered as a non-conventional ventilatory mode. The investigators aim to compare APRV with conventional mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS).
Eligibility Criteria
Inclusion Criteria: * Acute respiratory distress syndrome, according to the Berlin definition of ARDS, with adjusted pO2/FiO2 for altitude \<300, and less than 48 h of endotracheal mechanical ventilation Exclusion Criteria: * Pregnancy * Less than 18 years-old * Expected duration of mechanical ventilation less than 48 h * Preexisting conditions with an expected 3-month mortality exceeding 50% * Concurrent chemotherapy * Confirmed intracranial hypertension * Catastrophic cranial trauma or neuromuscular disorders that are known to prolong mechanical ventilation * Pneumothorax at enrollment (resolved or not) * Do-not-resuscitate order
Contact & Investigator
Miguel Ibarra-Estrada, Dr
PRINCIPAL INVESTIGATOR
Hospital Civil Fray Antonio Alcalde
Frequently Asked Questions
Who can join the NCT04221737 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Acute Respiratory Distress Syndrome. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04221737 currently recruiting?
Yes, NCT04221737 is actively recruiting participants. Contact the research team at drmiguelibarra@hotmail.com for enrollment information.
Where is the NCT04221737 trial being conducted?
This trial is being conducted at Guadalajara, Mexico.
Who is sponsoring the NCT04221737 clinical trial?
NCT04221737 is sponsored by Hospital Civil de Guadalajara. The principal investigator is Miguel Ibarra-Estrada, Dr at Hospital Civil Fray Antonio Alcalde. The trial plans to enroll 150 participants.