NCT07334418 Early General Anesthesia to Limit Experiences of Trauma During Cesarean Section-Pilot Study
| NCT ID | NCT07334418 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Pennsylvania |
| Condition | Cesarean Section |
| Study Type | INTERVENTIONAL |
| Enrollment | 600 participants |
| Start Date | 2026-04-06 |
| Primary Completion | 2027-11 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 600 participants in total. It began in 2026-04-06 with a primary completion date of 2027-11.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Some patients who undergo cesarean section under spinal or epidural anesthesia can experience severe pain. Some patients who experience this kind of pain can experience symptoms of post-traumatic stress disorder (PTSD) after pregnancy. Currently, the two main options for treating this pain are general anesthesia (full medically induced unconsciousness) and using intravenous medications to reduce the pain and decrease anxiety. The EAGLET-CS Pilot is a pilot randomized trial that will test the feasibility of comparing the impact of these two options for preventing PTSD in a rigorous way for those patients who experience pain during their cesarean section after the baby is out.
Eligibility Criteria
Inclusion Criteria: * Women aged 18 or older undergoing non-emergent cesarean delivery with primary neuraxial (epidural, spinal, or CSE) anesthesia. Eligible patients will be those who report severe pain during surgery, defined as pain that does not resolve with 2 trials of first-line pharmacologic therapies (e.g., epidural supplementation with local anesthetics; intravenous opioid analgesics). Exclusion Criteria: * We will exclude patients who require induction of general anesthesia prior to umbilical cord clamping and by clinician determination.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07334418 clinical trial?
This trial is open to female participants only, aged 18 Years or older, studying Cesarean Section. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07334418 currently recruiting?
Yes, NCT07334418 is actively recruiting participants. Contact the research team at eagletadmin@pennmedicine.upenn.edu for enrollment information.
Where is the NCT07334418 trial being conducted?
This trial is being conducted at Philadelphia, United States.
Who is sponsoring the NCT07334418 clinical trial?
NCT07334418 is sponsored by University of Pennsylvania. The trial plans to enroll 600 participants.