NCT07422844 Dynamic Network Response to TMS Treatment
| NCT ID | NCT07422844 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Goethe University |
| Condition | MDD |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2025-11-24 |
| Primary Completion | 2031-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2025-11-24 with a primary completion date of 2031-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This project aims to investigate whether symptom and brain networks and TMS stimulation sites can predict the response to TMS treatment of a transdiagnostic patient group with depressive syndrome. The TMS treatment is no intervention study - the investigators aim to observe patients who receive TMS as part of their psychiatric treatment. Additionally, the investigators aim to investigate exploratively how symptoms change over the course of treatment with TMS, that is, which symptoms respond first to treatment. Patients participate in a separate study first (DYNAMIC Central Project, registered with the German Clinical Trials Register: DRKS00038256), where MRI data is acquired. Within this project the symptomatology before, during and after the TMS-treatment are observed.
Eligibility Criteria
Inclusion Criteria: * Patients who are treated with TMS as an antidepressant will be recruited for study participation. The TMS treatment is carried out regardless of study participation. * Men and women will be included in a balanced ratio. * German language skills are required to ensure that questionnaires, interviews, and instructions are correctly understood, processed and answered. Exclusion Criteria: * Patients younger than 18 or older than 70 will be excluded * Participants who did not participate in the DYNAMIC central project (German Clinical Trials Register DRKS00038256) will be excluded. * Further exclusion criteria for participation are acute or chronic neurological diseases. * Patients who are pregnant will not be included in the study. * As we use app-based questionnaires, we cannot include participants without internet-enabled devices in the study.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07422844 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 70 Years, studying MDD. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07422844 currently recruiting?
Yes, NCT07422844 is actively recruiting participants. Contact the research team at repple@uni-frankfurt.de for enrollment information.
Where is the NCT07422844 trial being conducted?
This trial is being conducted at Frankfurt am Main, Germany.
Who is sponsoring the NCT07422844 clinical trial?
NCT07422844 is sponsored by Goethe University. The trial plans to enroll 100 participants.