Dynamic in Vivo PET Imaging and ex Vivo Biopsies From Skeletal Muscle and Adipose Tissue to Investigate the Effects of Exercise on Insulin Resistance and Mitochondrial Energetics in Type 2 Diabetes
Trial Parameters
Brief Summary
The overall aim of this pilot study is to investigate the effects of exercise training on skeletal muscle and adipose tissue insulin resistance in subjects with Type 2 Diabetes (T2D).
Eligibility Criteria
Inclusion Criteria: 1. Age 30-65 years 2. Men and women 3. Body mass index (BMI) between 25 and 45 kg/m2 4. Sedentary (1 day or less per week of structured exercise) 5. Type 2 diabetes mellitus determined by self-report or by a fasting glucose \>126mg/dl 6. Weight stable (± 2 kg) for prior 3 months 7. Willing to commit to the schedule of assessment visits, including the exercise intervention Exclusion Criteria: 1. Currently taking insulin, injectable incretin mimetics and thiazolidinediones 2. Taking more than two glucose-lowering medications 3. Resting blood pressure ≥ 160/100 mm Hg 4. Triglycerides ≥ 500 mg/dL 5. Any renal, cardiac, liver, lung, or neurological disease that in the opinion of the principal investigator would compromise participant safety or the participants' ability to complete the exercise training protocol 6. Any significant disease or unstable medical condition (i.e., coronary heart disease, chronic renal failure, chronic hepatic disease, severe pulmonary disease)