Driving Pressure-guided Lung Protective Ventilation
Trial Parameters
Brief Summary
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving pressure-guided lung protective ventilation can reduce postoperative oxygenation function in patients who have undergone surgical repair of acute type A aortic dissection. The primary outcomes is the incidence of postoperative hypoxemia (a partial pressure of arterial oxygen to inspiratory oxygen fraction ratio less than 300 mm Hg or a peripheral blood oxygen saturation less than 93% at any concentration of inspiratory oxygen) within 7 days after the surgery.
Eligibility Criteria
Inclusion Criteria: 1. Able to sign Informed Consent and Release of Medical Information Forms; 2. Age ≥ 14 years and ≤ 70 years old; 3. Being confirmed the diagnosis by chest computed tomography angiography and receiving the surgical repair of acute type A aortic dissection. Exclusion Criteria: 1. Age \< 14 years or \> 70 years old; 2. Sepsis before surgery; 3. Chronic pulmonary disease including lung infection or asthma requiring long-term pharmacotherapy; 4. History of lung tumor; 5. Obstructive sleep apnea hypopnea syndrome requiring long-term noninvasive mechanical ventilation support; 6. Heart failure requiring catecholamines or invasive mechanical ventilation support; 7. Body mass index \> 30 Kg·m-2; 8. Being reluctance to participate this study.