NCT07472244 Does the Development of the Repeated Bout Effect Depend on Oxidative Stress and Inflammation?
| NCT ID | NCT07472244 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Bath |
| Condition | Exercise Recovery |
| Study Type | INTERVENTIONAL |
| Enrollment | 52 participants |
| Start Date | 2025-09-01 |
| Primary Completion | 2027-02-28 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 52 participants in total. It began in 2025-09-01 with a primary completion date of 2027-02-28.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance. These performance decrements are attributable to oxidative stress and inflammation. Interestingly, a single bout of eccentric exercise can confer protective effects, ameliorating the negative consequences in subsequent bouts. This is termed the repeated bout effect (RBE), which would be of interest to athletes considering the detrimental effects of strenuous eccentric exercise. Athletes regularly consume supplements in hope of attenuating the performance decrements after strenuous eccentric exercise . However, considering the dose-response relationship between the initial performance decrement and the magnitude of the RBE , supplements may diminish the obtainment of the RBE. This notion remains untested, and so the proposed project is a double-blind, placebo-controlled, parallel group study aiming to assess the effects of acute vitamin C and ibuprofen supplementation on the development of the RBE. These two supplements were chosen as they are most frequently and successfully used in the literature to target oxidative stress (vitamin C) and inflammation (ibuprofen). Additionally, these doses (and the timing of supplements) were chosen to mimic protocols reporting beneficial effects
Eligibility Criteria
Inclusion Criteria: * 18 - 45 years of age * BMI 18.5 - 29.9 kg/m2 * Able to perform 20-minutes of bench stepping exercise * Capable and willing to provide consent (oral and written) Exclusion Criteria: * Familiarised with bench stepping exercise procedures * Not cleared for exercise by health questionnaires or physical activity readiness questionnaire * Participants exhibiting any alteration in clinical inflammation parameters due to other cause * Participants currently being prescribed any anti-inflammatory medications
Frequently Asked Questions
Who can join the NCT07472244 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 45 Years, studying Exercise Recovery. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07472244 currently recruiting?
Yes, NCT07472244 is actively recruiting participants. Visit ClinicalTrials.gov or contact University of Bath to inquire about joining.
Where is the NCT07472244 trial being conducted?
This trial is being conducted at Bath, United Kingdom.
Who is sponsoring the NCT07472244 clinical trial?
NCT07472244 is sponsored by University of Bath. The trial plans to enroll 52 participants.