NCT07408154 Direct vs Standard SLT for Glaucoma: A Noninferiority Trial
| NCT ID | NCT07408154 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Medical University of South Carolina |
| Condition | Open-angle Glaucoma (OAG) |
| Study Type | INTERVENTIONAL |
| Enrollment | 172 participants |
| Start Date | 2026-04-27 |
| Primary Completion | 2027-10 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 172 participants in total. It began in 2026-04-27 with a primary completion date of 2027-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.
Eligibility Criteria
Inclusion Criteria: * Age ≥18 years * Diagnosis of OAG (including exfoliative or pigmentary) or OHT * Gonioscopically open angle (visible scleral spur 360°) * Ability to consent and comply with follow-up Exclusion Criteria: * Angle-closure or secondary glaucomas * IOP \>35 mmHg despite therapy * Corneal pathology interfering with laser or IOP measurement * Recent ocular surgery (\<6 months) * Contraindications to study medications or procedures * Cognitive impairment preventing consent
Contact & Investigator
Jella An, MD
PRINCIPAL INVESTIGATOR
Medical University of South Carolina
Frequently Asked Questions
Who can join the NCT07408154 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Open-angle Glaucoma (OAG). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07408154 currently recruiting?
Yes, NCT07408154 is actively recruiting participants. Visit ClinicalTrials.gov or contact Medical University of South Carolina to inquire about joining.
Where is the NCT07408154 trial being conducted?
This trial is being conducted at Charleston, United States.
Who is sponsoring the NCT07408154 clinical trial?
NCT07408154 is sponsored by Medical University of South Carolina. The principal investigator is Jella An, MD at Medical University of South Carolina. The trial plans to enroll 172 participants.