Digitalized Surveillance Management for Liver Cancer Risk Population in Improving Eearly Diagnosis Efficancy in Chinese Population (dSEARCH)
Trial Parameters
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Brief Summary
The goal of this study is to evaluate whether the standardized liver cancer risk stratification management can effectively improve the early diagnosis rate of liver cancer in the targeted risk population in China.
Eligibility Criteria
Inclusion Criteria: 1. Voluntary participation in the clinical study; fully informed about the study and signed informed consent, willing to follow and capable of completing all trial procedures\[17\] 2. Age: 18 to 75 years old (including the cut-offs) 3. Subjects must meet at least one of the following criteria for enrollment. 1. Patients diagnosed with chronic hepatitis B in hospital or out of hospital: persistent positive hepatitis B surface antigen (HBsAg) for 6 months or more 2. Patients diagnosed with hepatitis C in hospital or out of hospital 3. Patients diagnosed with cirrhosis in hospital or out of hospital who meet at least one of the following criteria. 1. Liver biopsy showing cirrhosis (Ishak score ≥5 or Metavir score = 4); 2. Liver stiffness measurement (LSM) using FibroScan® (Echosens™, Paris, France) ≥12.0 kPa when TB was normal and ALT ≤ 40 IU/mL, or LSM ≥ 17.0 kPa when TB was normal and ALT \< 200 IU/mL; 3. Abdominal imaging results showing characteristic of cirrhosis