NCT05833828 Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery
| NCT ID | NCT05833828 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universität Münster |
| Condition | Vasoplegia |
| Study Type | OBSERVATIONAL |
| Enrollment | 40 participants |
| Start Date | 2023-08-24 |
| Primary Completion | 2025-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 40 participants in total. It began in 2023-08-24 with a primary completion date of 2025-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
Eligibility Criteria
Inclusion Criteria: 1. adult patients undergoing on- or off-pump coronary artery bypass graft surgery 2. written informed consent Exclusion Criteria: 1. emergency surgery in the context of acute coronary syndrome 2. ACE-inhibitor or Angiotensin 1 (AT1)-receptor-blocker intake that was not paused on the day of surgery 3. Chronic kidney disease with estimated glomerular filtration rate (eGFR)\<30ml/min/1.73m² 4. Severe structural lung disease (asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, chronic obstructive pulmonary disease (COPD) Gold 3-4, lung fibrosis) 5. Chronic pulmonary hypertension 6. Pregnancy or breastfeeding 7. Persons with any kind of dependency on the investigator or employed by the institution responsible or investigator 8. Persons held in an institution by legal or official order
Contact & Investigator
Alexander Zarbock, MD
STUDY CHAIR
University Hospital Muenster, Dept. of Anesthesiology, Intensive Care Therapy and Pain Medicine
Frequently Asked Questions
Who can join the NCT05833828 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Vasoplegia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05833828 currently recruiting?
Yes, NCT05833828 is actively recruiting participants. Contact the research team at aki@anit.uni-muenster.de for enrollment information.
Where is the NCT05833828 trial being conducted?
This trial is being conducted at Berlin, Germany, Münster, Germany.
Who is sponsoring the NCT05833828 clinical trial?
NCT05833828 is sponsored by Universität Münster. The principal investigator is Alexander Zarbock, MD at University Hospital Muenster, Dept. of Anesthesiology, Intensive Care Therapy and Pain Medicine. The trial plans to enroll 40 participants.