Trial Parameters
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Brief Summary
Dietary Reference Intakes (DRIs) for iron are based on a relatively small number of studies in European populations. This research study will determine iron needs in a representative sample of adults living in the US using the iron isotope dilution technique. Following administration and equilibration of a stable iron isotope, participants will be followed for a 12 week study period. Blood will be collected every 4 weeks and the isotopic composition will be determined. Results will help update dietary iron guidelines making sure they better match the specific needs of the US population.
Eligibility Criteria
Inclusion Criteria: * Males and premenopausal females age 18-50 y * Previously participated in an iron stable isotope study or willing to consume an oral stable iron isotope and undergo a one-year equilibration period * Willing to refrain from iron-containing supplements for the duration of the study * Willing to refrain from tobacco smoking for the duration of the study * Have not donated blood 3 months prior to the start of the study and willing to refrain from donating blood for the duration of the study * Willing to have blood stored for future use * Able and willing to comply with study requirements and consent to participate Exclusion Criteria: * Females: pregnant or lactating or plans to become pregnant during the study period * Inability to provide informed consent and engage in informed consent procedures * Plans to relocate outside the study area