NCT03667027 Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
| NCT ID | NCT03667027 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Health Network, Toronto |
| Condition | Diaphragm Injury |
| Study Type | OBSERVATIONAL |
| Enrollment | 40 participants |
| Start Date | 2019-04-01 |
| Primary Completion | 2025-08-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 40 participants in total. It began in 2019-04-01 with a primary completion date of 2025-08-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
Eligibility Criteria
Inclusion Criteria (Cases): * Receiving a respiratory support modality as a bridge to lung transplantation * Formally listed for transplantation Inclusion Criteria (Control Group 1): \- Undergoing lung transplantation for either obstructive or restrictive lung disease Inclusion Criteria (Control Group 2): \- Undergoing elective thoracic surgery without any prior history of chronic pulmonary parenchymal disease Exclusion Criteria (Cases and Controls): * Previously diagnosed with neuromuscular disorder * Received invasive mechanical ventilation for \>48 hours in the preceding four weeks * Thoracic cage deformity
Contact & Investigator
Ewan Goligher, MD, PhD
PRINCIPAL INVESTIGATOR
University Health Network, Toronto
Frequently Asked Questions
Who can join the NCT03667027 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Diaphragm Injury. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03667027 currently recruiting?
Yes, NCT03667027 is actively recruiting participants. Contact the research team at rongyu.jin@uhn.ca for enrollment information.
Where is the NCT03667027 trial being conducted?
This trial is being conducted at Toronto, Canada.
Who is sponsoring the NCT03667027 clinical trial?
NCT03667027 is sponsored by University Health Network, Toronto. The principal investigator is Ewan Goligher, MD, PhD at University Health Network, Toronto. The trial plans to enroll 40 participants.