NCT06981494 Dexmedetomidine Versus Dexmedetomidine and Ketamine (Ketodex) in Ear and Nose Surgeries
| NCT ID | NCT06981494 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Sohag University |
| Condition | Ear and Nose Surgeries With Hypotensive Anaesthesia e.g FESS , MLS , TURBINECTOMY |
| Study Type | INTERVENTIONAL |
| Enrollment | 84 participants |
| Start Date | 2025-02-05 |
| Primary Completion | 2025-08-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 84 participants in total. It began in 2025-02-05 with a primary completion date of 2025-08-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study aims to compare the efficacy, safety and overall effectiveness of dexmedetomidine and dexmedtomidine and ketamine (ketodex) in achieving controlled hypotension during Ear and nose surgeries. \- Assessment the analgesic and sedative role of both drugs.
Eligibility Criteria
Inclusion Criteria * Age Range: Patients aged 18-60 years who are scheduled for elective Ear and nose surgeries requiring controlled hypotensive anesthesia. * ASA Classification: Patients classified as American Society of Anesthesiologists (ASA) physical status I or II. * Surgical Procedures: Individuals undergoing specific ear and nose surgeries where controlled hypotensive anesthesia is typically indicated. * Stable Cardiovascular Health: Patients with stable cardiovascular function, without significant history of uncontrolled hypertension , hypotension or ischaemic heart diseases. Exclusion Criteria * Severe Cardiovascular Conditions: Patients with severe cardiovascular diseases such as congestive heart failure, uncontrolled hypertension , arrhythmias or ischaemic heart diseases . * Any cardiac patients. * Respiratory Conditions: Individuals with significant respiratory conditions like chronic obstructive pulmonary disease (COPD) or severe asthma. * Drug Allergies: Patients with known hypersensitivity or allergic reactions to dexmedetomidine, ketamine or any other components of the study drugs. * Pregnancy or Lactation: Pregnant or breastfeeding women, due to potential risks to the fetus or infant. * Chronic Medication Use: Patients on chronic medications that could interfere with blood pressure regulation or interact with the study drugs (e.g., beta-blockers, MAO inhibitors). * Patients with chronic liver or renal diseases. * Psychiatric or Neurological Disorders: Individuals with severe psychiatric or neurological disorders that could impact the study outcomes or the patient's ability to consent. * Substance Abuse: Patients with a history of substance abuse, particularly involving sedatives or opioids, which could affect anesthesia requirements or recovery. * Coagulation Disorders: Individuals with coagulation disorders or on anticoagulant therapy, due to the increased risk of bleeding.
Frequently Asked Questions
Who can join the NCT06981494 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Ear and Nose Surgeries With Hypotensive Anaesthesia e.g FESS , MLS , TURBINECTOMY. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06981494 currently recruiting?
Yes, NCT06981494 is actively recruiting participants. Visit ClinicalTrials.gov or contact Sohag University to inquire about joining.
Where is the NCT06981494 trial being conducted?
This trial is being conducted at Sohag, Egypt.
Who is sponsoring the NCT06981494 clinical trial?
NCT06981494 is sponsored by Sohag University. The trial plans to enroll 84 participants.