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Recruiting NCT06206369

Developing Trustworthy Artificial Intelligence (AI)-Driven Tools to Predict Vascular Disease Risk and Progression

Trial Parameters

Condition Aneurysm Abdominal
Sponsor Amsterdam UMC, location VUmc
Study Type OBSERVATIONAL
Phase N/A
Enrollment 11,000
Sex ALL
Min Age 40 Years
Max Age 90 Years
Start Date 2023-10-31
Completion 2029-05-01
Interventions
No intervention, retrospective study

Brief Summary

The VASCULAID-RETRO study, within the broader VASCULAID project, aims to create artificial intelligence (AI) algorithms that can predict cardiovascular events and the progression of abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD). The study plans to gather and analyze data from at least 5000 AAA and 6000 PAD patients, combining existing cohorts and retrospectively collected data. During this project, AI tools will be developed to perform automatic anatomical segmentation and analyses on multimodal imaging. AI prediction algorithms will be developed based on multisource data (imaging, medical history, -omics).

Eligibility Criteria

Inclusion Criteria: * Males and females, 40-90 years old, with an AAA \>3cm. This includes patients with infrarenal, juxtarenal, suprarenal, iliac (defined as 1.5x its normal diameter) aneurysms, as well as mycotic aneurysms. Patients that have had interventions or ruptures will also be included * Males and females, 40-90 years old, all PAD patients (Fontaine stages 1,2,3, and 4). Exclusion Criteria: * Patients with an ascending, thoracic, thoracoabdominal (type 1-3) aneurysm.

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