NCT05980793 Denervation for Osteoarthritis in the PIP-joint Efficacy Study (DOPS)
| NCT ID | NCT05980793 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Karolinska Institutet |
| Condition | Osteoarthritis Finger |
| Study Type | INTERVENTIONAL |
| Enrollment | 90 participants |
| Start Date | 2023-09-25 |
| Primary Completion | 2028-07-15 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
The goal of this clinical trial is to compare the effects of a surgical and a non-surgical treatment method in patients with osteoarthritis in the proximal interphalangeal (PIP) joint. The main questions it aims to answer are: * Are the treatments effective? * Is the surgical treatment more effective than the non-surgical treatment? Participants will receive surgical treatment (PIP joint denervation) or non surgical treatment (patient education plus exercise). Researchers will compare the non-surgical and surgical groups to see if pain, patient-reported function, quality of life, movement and grip strength differs between the groups.
Eligibility Criteria
Inclusion Criteria: * Age ≥ 18 years. * Chronic symptomatic osteoarthritis in the PIP-joint. * Radiological signs of osteoarthritis on posteroanterior and lateral radiographs assessed by the Kellgren-Lawrence classification (grade II-IV) (Kellgren \& Lawrence, 1957). * Clinical signs of PIP-joint arthritis. Exclusion Criteria: * Inflammatory arthritis. * Ongoing infection in the hand. * Inability to co-operate with the follow-up protocol. * Intra-articular glucocorticoid, PRP or Hyaluronic acid injections in the affected joint less than 3 months prior to enrollment.