NCT07095608 Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain
| NCT ID | NCT07095608 |
| Status | Recruiting |
| Phase | — |
| Sponsor | New York University |
| Condition | Oral Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 80 participants |
| Start Date | 2025-09-01 |
| Primary Completion | 2029-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 80 participants in total. It began in 2025-09-01 with a primary completion date of 2029-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This is a prospective study involving human participants. Pressure and stretch sensitivity measures between oral cancer patients and healthy subjects will be compared. Pain stimulation will be conducted on the site of the cancer in 40 oral cancer patients, and on the tongue in 40 healthy volunteers, using pressure and stretch sensitivity tests.
Eligibility Criteria
Inclusion Criteria: For healthy subjects to be eligible to participate in this study, an individual must meet all of the following criteria: * Provide signed and dated informed consent form * Willing to comply with all study procedures and be available for the duration of the study * Male or female, at least 18 years of age * In good general health as evidenced by medical history For oral cancer patients to be eligible to participate in this study, an individual must meet all of the following criteria: * Provide signed and dated informed consent form * Willing to comply with all study procedures and be available for the duration of the study * Male or female, at least 18 years of age * Biopsy-proven squamous cell carcinoma (SCC) of the oral cavity that requires surgical resection * Lesion is at least 1 cm in greatest surface dimension Exclusion Criteria: * Healthy subjects who meet any of the following criteria will be excluded from participation in this study: * Clinically and/or histologically proven oral pre-cancer, oral cancer * Pregnancy or lactation (Female subjects of child-bearing potential will have a rapid urine pregnancy test) * Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study. Oral cancer patients who meet any of the following criteria will be excluded from participation in this study: * History of prior surgical, chemotherapeutic, or radiation treatment for head and neck cancer * Pregnancy or lactation * Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study. For participants with impaired kidney function (chronic kidney/renal disease) who wish to participate in the proposed research study, consultation with their primary care provider will be done prior to enrollment to determine safety
Contact & Investigator
Brian L Schmidt, DDS
PRINCIPAL INVESTIGATOR
NYU College of Dentistry
Frequently Asked Questions
Who can join the NCT07095608 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Oral Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07095608 currently recruiting?
Yes, NCT07095608 is actively recruiting participants. Contact the research team at ym2891@nyu.edu for enrollment information.
Where is the NCT07095608 trial being conducted?
This trial is being conducted at New York, United States.
Who is sponsoring the NCT07095608 clinical trial?
NCT07095608 is sponsored by New York University. The principal investigator is Brian L Schmidt, DDS at NYU College of Dentistry. The trial plans to enroll 80 participants.
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