Deep Sedation With Pre-emptive Endotracheal Intubation for Advanced Bronchoscopy Procedures
Trial Parameters
Brief Summary
Bronchoscopy is crucial for diagnosing and treating respiratory diseases and is recommended under sedation. Deep sedation improves patient comfort and procedural efficiency, especially in complex cases, by reducing movement and coughing. However, it carries risks of respiratory depression and airway obstruction, potentially requiring premature termination or urgent intubation. Determining the optimal timing for intubation can be challenging despite proper monitoring. To enhance safety, the investigator has performed bronchoscopy under deep sedation with preemptive intubation for years, sharing this experience with other hospitals. This study aims to evaluate its safety and feasibility through a multicenter prospective observational approach.
Eligibility Criteria
Inclusion Criteria: * Patients requiring a bronchoscopy-assisted procedure for diagnostic or therapeutic purposes * Individuals who voluntarily consent to participate in the clinical study and sign a written informed consent form Exclusion Criteria: * Patients who have experienced acute myocardial infarction or acute stroke within the past six weeks * Patients with contraindications to bronchoscopy (e.g., severe respiratory or cardiovascular comorbidities) * Patients with a history of allergy to benzodiazepines, propofol, fentanyl, or flumazenil * Patients with genetic disorders such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption * Patients with a severe hypersensitivity reaction to dextran 40 * Patients with a history of acute angle-closure glaucoma * Pregnant women * Prisoners * Patients with psychiatric disorders * Patients classified as ASA Physical Status IV or V by the American Society of Anesthesiologists (ASA) * Any other patients deemed u