Deep rTMS for Mild Neurocognitive Disorder in Older Adults
Trial Parameters
Brief Summary
This study aims to: (1) assess the feasibility and tolerability of three deep transcranial magnetic stimulation (dTMS) coils H1, H4, and H7 in older adults with mild neurocognitive disorder (mild NCD); and (2) evaluate changes in cognition through neuropsychological testing, brain activity through EEG, and mood and sleep through self-report questionnaires. Participants will be assigned to one of three arms: H1- coil vs. H4-coil vs. H7-coil, and all participants will complete assessments examining dTMS side effects, mental health symptoms, and cognition. EEG, questionnaires, and CNS vital signs will be measured at baseline, midpoint (after 10th session- before dTMS treatment on visit 11), and end point, as well as follow up. Collectively, the study will address the absolute and differential feasibility and tolerability of the H1, H4 and H7 coils to provide preliminary data for a future randomized controlled trial comparing this novel intervention to a sham stimulation (placebo) control.
Eligibility Criteria
Inclusion Criteria: * 60 - 90 years old * Able to provide informed consent to participate in the study * Subjective concern of mild decline in cognitive function over the past year * Mild impairment in cognitive performance * Preserved independence in everyday activities * Independently mobile (e.g., participants must be able to get in and out of a chair on their own) * Participants will be required to be on stable dosages of other psychotropic medications for at least 4 weeks prior to screening Exclusion Criteria: * Currently receiving treatment or subjective need for treatment for bipolar I or II disorder; psychotic disorder * Active suicidal behavior * Severe depression and/or anxiety * Other neurological or psychiatric disorders accounting for the cognitive deficits * Impairment in basic and/or instrumental activities of daily living * Substance use disorder (other than tobacco use disorder) in the past 3 months before entering the study * Traditional contraindications to rTMS: Int