NCT07281625 Decompressive Laminectomy Versus Laminectomy With Transpedicular Fixation in Lumbar Spinal Stenosis
| NCT ID | NCT07281625 |
| Status | Recruiting |
| Phase | EARLY_Phase 1 |
| Sponsor | Punjab Health Care Commission |
| Condition | Lumbar Spinal Stenosis |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-10-01 |
| Primary Completion | 2025-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 60 participants in total. It began in 2025-10-01 with a primary completion date of 2025-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Lumbar spinal stenosis is a condition where the spinal canal becomes narrowed and can cause symptoms such as back pain, numbness, leg pain, and difficulty walking. Surgery is often considered when symptoms do not improve with medical treatment. This study will compare two types of surgery used to treat lumbar spinal stenosis: decompressive laminectomy alone and decompressive laminectomy with transpedicular screw fixation. Patients will be randomly assigned to one of the two surgical options. The purpose of this study is to determine which approach provides better pain relief, improved function, fewer complications, and better spinal stability after surgery.
Eligibility Criteria
Inclusion Criteria: * Age 30-60 years * Diagnosis of lumbar spinal stenosis based on MRI criteria (anteroposterior canal diameter \<10-15 mm or cross-sectional area \<75-145 mm²) * Multilevel disc herniation * Degenerative disc disease with Pfirrmann grade 3-5 on T2-weighted MRI * Failure of at least six weeks of conservative treatment Exclusion Criteria: * Previous history of lumbar spine surgery * Spinal malignancy * Congenital lumbar spinal stenosis, scoliosis, or kyphoscoliosis * Lumbar spondylolisthesis grade 3-5 * Significant comorbidities including diabetes mellitus or ischemic heart disease
Contact & Investigator
Hira Umar, MBBS
PRINCIPAL INVESTIGATOR
SIMS SIUT
Frequently Asked Questions
Who can join the NCT07281625 clinical trial?
This trial is open to participants of all sexes, aged 30 Years or older, up to 60 Years, studying Lumbar Spinal Stenosis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07281625 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT07281625 currently recruiting?
Yes, NCT07281625 is actively recruiting participants. Contact the research team at quickcareclinicdr03@gmail.com for enrollment information.
Where is the NCT07281625 trial being conducted?
This trial is being conducted at Lahore, Pakistan.
Who is sponsoring the NCT07281625 clinical trial?
NCT07281625 is sponsored by Punjab Health Care Commission. The principal investigator is Hira Umar, MBBS at SIMS SIUT. The trial plans to enroll 60 participants.