NCT06637150 Dalpicilib-Enhanced vs. Standard Endocrine Therapy in ER+ HER2- Early Breast Cancer
| NCT ID | NCT06637150 |
| Status | Recruiting |
| Phase | Phase 3 |
| Sponsor | Fudan University |
| Condition | Breast Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 1,388 participants |
| Start Date | 2025-01-09 |
| Primary Completion | 2030-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 3 trials are large pivotal studies comparing the treatment to current standard of care or placebo. Your participation directly contributes to the evidence needed for regulatory approval.
This trial targets 1,388 participants in total. It began in 2025-01-09 with a primary completion date of 2030-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study aims to conduct a randomized controlled clinical trial to compare the efficacy and safety of dalpicilib combined with endocrine therapy versus standard endocrine therapy in ER-positive, HER2-negative, lymph node-negative patients with risk factors, in order to further optimize the regimen for adjuvant endocrine therapy in breast cancer.
Eligibility Criteria
Inclusion Criteria: 1. Women aged 18-70 years 2. ECOG score of 0-1 3. Histologically confirmed unilateral invasive cancer (regardless of pathology type) 4. No macroscopic or microscopic tumor residue after surgical resection 5. Early-stage breast cancer, pathologically confirmed as ER-positive and HER2-negative (ER-positive defined as immunohistochemical detection of ER \>10% of tumor cells positive; HER2 0-1+ or HER2 2+ but FISH negative, with no amplification, defined as HER2-negative) 6. Postoperative pathological staging of pT1c or above, N0M0, and meeting one of the following criteria: (1) G3; (2) G2 and meeting one of the following: i. Ki-67 ≥20%; ii. 21-gene recurrence score ≥26 or high genomic risk profile; iii. Age ≤40 years and vascular invasion positive 7. No prior neoadjuvant treatment 8. Time from surgery or completion of chemotherapy or radiotherapy (whichever occurs later) to randomization does not exceed 8 weeks 9. Good postoperative recovery, at least 1 week after surgery 10. Normal function of major organs, meeting the following criteria: (1) Hematological criteria: HB ≥90 g/L (no blood transfusion in the last 14 days); ANC ≥1.5 × 10\^9 /L; PLT ≥100 × 10\^9 /L; (2) Biochemical criteria: TBIL ≤1.5 × ULN (upper limit of normal); ALT and AST ≤3 × ULN; serum Cr ≤1.5 × ULN 11. Women of childbearing age must use contraception during treatment 12. Subjects voluntarily join this study, sign informed consent, demonstrate good compliance, and cooperate with follow-up Exclusion Criteria: 1. Bilateral breast cancer or ductal/lobular carcinoma in situ (DCIS/LCIS) 2. Received treatment for advanced disease 3. Metastasis at any site 4. Any tumor \> T4a (with skin involvement, fixation, inflammatory breast cancer) 5. Clinically or radiologically suspected malignancy in the contralateral breast not confirmed and requiring biopsy 6. Received neoadjuvant therapy, including chemotherapy, radiotherapy, and endocrine therapy 7. History of malignant tumors within the past 5 years (excluding basal cell carcinoma of the skin and cervical carcinoma in situ), including contralateral breast cancer 8. Patient has been enrolled in other clinical trials 9. Patient has severe systemic diseases and/or uncontrolled infections that prevent participation in the study 10. Severe cardiovascular or cerebrovascular diseases within 6 months prior to randomization (e.g., unstable angina, chronic heart failure, uncontrolled hypertension \>150/90 mmHg, myocardial infarction, or stroke) 11. Known allergy to relevant medications 12. Women of childbearing age who refuse contraception during treatment and for 8 weeks after treatment completion 13. Pregnant or breastfeeding women 14. Positive pregnancy test before drug administration after joining the trial 15. Individuals with mental illness or cognitive impairment who cannot understand the trial protocol and its side effects, unable to comply with the protocol and follow-up (systematic assessment required prior to enrollment) 16. Individuals without personal freedom and independent civil capacity
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06637150 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 70 Years, studying Breast Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06637150 trial and what does that mean for participants?
Phase 3 trials are large-scale studies comparing the new treatment to existing standards of care or a placebo. They provide the evidence needed for regulatory approval. This trial targets 1,388 participants.
Is NCT06637150 currently recruiting?
Yes, NCT06637150 is actively recruiting participants. Contact the research team at zhimingshao@fudan.edu.cn for enrollment information.
Where is the NCT06637150 trial being conducted?
This trial is being conducted at Shanghai, China.
Who is sponsoring the NCT06637150 clinical trial?
NCT06637150 is sponsored by Fudan University. The trial plans to enroll 1,388 participants.
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