Daily Intake of Multivitamin & Mineral Supplementation Effects on Biological Age of Relatively Healthy Middle-aged Individuals
Trial Parameters
Brief Summary
Micronutrients, such as vitamins and minerals, are required to sustain fundamental physiological processes in individuals. As individuals age, the risk of having suboptimal levels of micronutrients increases due to several age-related changes affecting their digestion and assimilation processes. Suboptimal levels of micronutrients have been associated with increased risk of chronic diseases and accelerated ageing. Three years intake of a multivitamin and mineral supplement (MVM) improved global cognition, episodic memory and executive function in older adults. Furthermore, suboptimal micronutrient levels have been associated with a higher biological age, and diet and lifestyle interventions might lower the biological age measured by methylation clocks. Therefore, further evaluation is warranted to determine if MVM supplementation could improve the biological age and clinical outcomes in individuals with a higher biological age.
Eligibility Criteria
Inclusion Criteria Participants will be recruited if they fall in the following categories: 1. Relatively healthy middle aged (40-60 years) man or woman; 2. Completed the pre-screening requirements and has managed to schedule the screening visit; 3. Met the randomization criteria after the screening visit i.e., your biological age (as measured by blood DNA methylation) is greater than the chronological age; 4. Able to attend all 4 research visits for screening and research data collection at the NUHS Centre for Healthy Longevity (CHL) at Alexandra Hospital or MD11, National University of Singapore. 5. Willing to wear an OURA ring for 14 consecutive days after each study visits. 6. Willing to download study platform application into their mobile phone throughout the study period. Exclusion Criteria Participants will NOT be recruited if they fall in any one or more of the following categories: 1. BMI lower than 18 kg/m2 or higher than or equal to 30 kg/m2 \[25\]; 2. Pre-existing, or hist