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Recruiting NCT06160635

D-SOLVE Cohorts (Cohort a and B)

Trial Parameters

Condition HDV
Sponsor Hannover Medical School
Study Type OBSERVATIONAL
Phase N/A
Enrollment 750
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2023-02-22
Completion 2026-09-30

Brief Summary

Hepatitis D is by far the most severe form of chronic viral hepatitis, frequently leading to liver failure, hepatocellular carcinoma and death. Hepatitis D is caused by coinfection Hepatitis D is caused by co-infection with hepatitis B virus (HBV) and hepatitis D virus (HDV). This multicenter cohort should enable a comprehensive and unbiased biomarker screening of well-defined HDV-infected patients, followed by mechanistic studies to determine the functional role of distinct molecules. Patient surveillance strategies and antiviral treatment approaches could be personalized which should reduce clinical and social disease burden, improve quality of life and save direct and indirect costs caused by HDV infection.

Eligibility Criteria

Inclusion Criteria: * Anti-HDV positive * ≥18 years old * Sex: m/f/d * Informed consent for prospective procedures Exclusion Criteria: * Anti-HDV negative

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