NCT07590362 D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients
| NCT ID | NCT07590362 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Sohag University |
| Condition | Chronic Obstructive Pulmonary Disease (COPD) |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2026-04-15 |
| Primary Completion | 2027-05 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2026-04-15 with a primary completion date of 2027-05.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success from invasive mechanical ventilation in COPD patients. Diaphragmatic ultrasound measurements will be performed during spontaneous breathing trials, and patients will be followed for 72 hours after extubation to assess weaning outcomes.
Eligibility Criteria
Inclusion Criteria: * Mechanically ventilated COPD patients fulfilling standard weaning readiness criteria. * Invasive mechanical ventilation for more than 24 hours before spontaneous breathing trial. * Hemodynamically stable without significant vasopressor support. * Adequate oxygenation with FiO2 ≤ 0.5 and PEEP ≤ 8 cmH2O . * Preserved mental status and ability to initiate spontaneous breathing. * Successful tolerance of spontaneous breathing trial conducted on CPAP mode with pressure support ≤ 8 cmH2O. Exclusion Criteria: * Refusal of consent * Neuromuscular disease, phrenic nerve palsy, or diaphragmatic paralysis. * Large pneumothorax or pathology interfering with ultrasound assessment. * Terminal extubation. * Recent major thoracic surgery. * Poor sonographic window despite repeated attempts.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07590362 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Chronic Obstructive Pulmonary Disease (COPD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07590362 currently recruiting?
Yes, NCT07590362 is actively recruiting participants. Contact the research team at ahmed_ateff_post@med.sohag.edu.eg for enrollment information.
Where is the NCT07590362 trial being conducted?
This trial is being conducted at Sohag, Egypt.
Who is sponsoring the NCT07590362 clinical trial?
NCT07590362 is sponsored by Sohag University. The trial plans to enroll 100 participants.
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