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Recruiting NCT06848881

Cryoablation vs Thoracoscopic Surgery for GGN

Trial Parameters

Condition Ground-Glass Opacity
Sponsor Shanghai Chest Hospital
Study Type INTERVENTIONAL
Phase N/A
Enrollment 160
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2025-04-20
Completion 2030-04-15
Interventions
CryoablationThoracoscopic Surgery

Brief Summary

The aim of this study is to investigate the efficacy and safety of Cryoablation and Thoracoscopic Surgery in the treatment of pulmonary ground-glass nodules.

Eligibility Criteria

Inclusion Criteria: 1. Patients ≥ 18 years old. 2. The size of the GGN is 8-20mm (with less than 25% solid component), and the number of nodules requiring treatment in the short term is less than 3. 3. Pathological confirmation of the GGN as non-small cell lung cancer; or progression of the GGN during at least 3 months of follow-up, including enlargement of the largest diameter, increase in solid component, or the appearance of a significant solid component in a previously pure GGN, with multidisciplinary discussion (including radiology, thoracic surgery, and pulmonology) suggesting malignancy. 4. No lymph node, pulmonary, or distant metastasis to other organs. 5. After multidisciplinary evaluation, the patient is considered capable of tolerating both surgical and ablation procedures. 6. Unsuitable for radiation therapy or refusal of radiation therapy. 7. Willing to participate in this clinical study and sign the informed consent form. Exclusion Criteria: 1. Patients in poor general co

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