| NCT ID | NCT02978911 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Hospices Civils de Lyon |
| Condition | Cranial Nerve Palsy |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2016-07-12 |
| Primary Completion | 2026-07-12 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2016-07-12 with a primary completion date of 2026-07-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Introduction: The skull base tumors surgery remains a challenge since numerous cranial nerves or vessels closely surround them. Recently, diffusion tensor imaging has developed with the tractography following white fibers and visualizing functional tracts. Cranial nerves tractography could allow predicting their displacement by skull base tumors that may help the surgeon to spare them along the surgery. Methods: Preoperative cerebral MRI was performed on patients who presented with skull base tumors. A 3 tesla MRI machine was used to acquire DTI sequence with specific parameters: 32 directions, slice thickness 2 mm, echo time 86 ms, repetition time 12000 ms, matrix 128x128, b-value 1000 s.mm-1. An anatomic sequence hyperT2 was overlaid as reference. Distortion was corrected by topup and eddy functions from FSL. Cranial nerves fibers were probabilistically tracked with Mrtrix3. Cranial nerves were selected according to their location around the tumor. The "radiological" expected position of the cranial nerve was compared to its "operative" real position.
Eligibility Criteria
Inclusion Criteria: * Patients who present a skull base tumor that requires surgical removal * Patients adult, informed and agreed Exclusion Criteria: * Pregnant women * Patients under 18 years old, unable to legally consent
Contact & Investigator
Timothée Jacquesson, MD
PRINCIPAL INVESTIGATOR
Hospices Civils de Lyon
Frequently Asked Questions
Who can join the NCT02978911 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Cranial Nerve Palsy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT02978911 currently recruiting?
Yes, NCT02978911 is actively recruiting participants. Contact the research team at timothee.jacquesson@neurochirurgie.fr for enrollment information.
Where is the NCT02978911 trial being conducted?
This trial is being conducted at Bron, France.
Who is sponsoring the NCT02978911 clinical trial?
NCT02978911 is sponsored by Hospices Civils de Lyon. The principal investigator is Timothée Jacquesson, MD at Hospices Civils de Lyon. The trial plans to enroll 120 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.