NCT07410702 Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia
| NCT ID | NCT07410702 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Huazhong University of Science and Technology |
| Condition | Altered State of Consciousness |
| Study Type | OBSERVATIONAL |
| Enrollment | 250 participants |
| Start Date | 2026-02-10 |
| Primary Completion | 2026-10-20 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 250 participants in total. It began in 2026-02-10 with a primary completion date of 2026-10-20.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective observational study is designed to investigate and compare the dynamic features of whole-brain electroencephalogram (EEG) during the induction of unconsciousness using various anesthetic agents with distinct pharmacological mechanisms. The primary objective is to identify common, drug-agnostic EEG biomarkers of anesthetic depth and to develop a novel, universal assessment system that addresses the limitations of the currently prevalent Bispectral Index (BIS), which demonstrates variable sensitivity across different anesthetics. Approximately 250 adult patients (ASA I-II) scheduled for elective surgery under general anesthesia will be enrolled. Patients will undergo preoperative cognitive assessment prior to induction. During anesthesia induction, 32-channel EEG signals will be continuously recorded alongside BIS values and behavioral state assessments using the MOAA/S scale as the reference standard. Patients will receive one of the following intravenous anesthetics for induction: Propofol, Ciprofol, Remimazolam, Esketamine, or Fospropofol. Features will be extracted from the preprocessed EEG data. Statistical analyses will compare these features across drug groups and in relation to behavioral state transitions. Machine learning models (e.g., Random Forest) will then be trained to classify states of consciousness based on the extracted EEG features, with model performance validated against the behavioral gold standard. The study aims to establish a more robust and generalizable neurophysiological framework for monitoring anesthetic depth, potentially improving the precision and safety of clinical anesthesia management.
Eligibility Criteria
Inclusion Criteria: 1. Age ≥ 18 years. 2. Scheduled to undergo elective surgery requiring general anesthesia with endotracheal intubation or laryngeal mask airway (LMA). 3. American Society of Anesthesiologists (ASA) Physical Status Class I to III. 4. Preoperative Mini-Mental State Examination (MMSE) score ≥ 24, indicating normal cognitive function. 5. Body mass index (BMI) ≤ 30 kg/m². 6. Ability to understand the study and provide written informed consent. Exclusion Criteria: 1. History of drug abuse or dependence. 2. Known major neurological disorders (e.g., epilepsy, stroke, neurodegenerative diseases). 3. History of major psychiatric disorders. 4. Known or suspected pregnancy. 5. Inability to provide informed consent due to cognitive impairment, language barrier, or any other reason.
Contact & Investigator
Pu Zhou, PhD.
PRINCIPAL INVESTIGATOR
Huazhong University of Science and Technology
Frequently Asked Questions
Who can join the NCT07410702 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Altered State of Consciousness. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07410702 currently recruiting?
Yes, NCT07410702 is actively recruiting participants. Contact the research team at hzheng@hust.edu.cn for enrollment information.
Where is the NCT07410702 trial being conducted?
This trial is being conducted at Wuhan, China.
Who is sponsoring the NCT07410702 clinical trial?
NCT07410702 is sponsored by Huazhong University of Science and Technology. The principal investigator is Pu Zhou, PhD. at Huazhong University of Science and Technology. The trial plans to enroll 250 participants.