NCT07690358 Concentrations of Nitrous Oxide in Blood, Exhaled Air and Urine After Various Types of Exposure.
| NCT ID | NCT07690358 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Aarhus |
| Condition | Intoxication by Drug |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2026-06-01 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2026-06-01 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The study examines the concentrations of nitrous oxide that are achieved in blood, exhaled air, and urine after three different exposures to nitrous oxide: inhalation of three or four cartridges of nitrous oxide released in a car cabin in a switched-off car, consumption of 100 g of whipped cream in which nitrous oxide is used as a propellant, and exposure through work as a midwife in a delivery room. The concentrations in blood and exhaled air are measured for up to 1 hour after exposure, and in urine for up to 2 hours after exposure. The concentrations in blood and urine are measued with gas chromatography and mass spectrometry, while the concentration in exhaled air is measured by a sensor using an NDIR sensor (Olythe, France).
Eligibility Criteria
For arm 1, 2, and 3: Inclusion Criteria: * Age 18-65 years * Able to understand Danish * Willing to use effective contraception for 24 hours after the end of exposure (oral contraceptives, contraceptive implant, transdermal patch, vaginal ring, or injectable contraceptives) * Written informed consent Exclusion Criteria: * Current or past abuse of drugs, nitrous oxide (N₂O), or alcohol * A psychiatric disorder requiring medical treatment, including severe depression * A diagnosis of epilepsy * Symptoms of peripheral neuropathy * Significant cardiac or pulmonary disease * Previous allergic or adverse reaction to N₂O * Diving within the past 2 days * Inability to refrain from diving for 2 days after the study * Occupational exposure to N₂O * Use of N₂O within the past 3 months * Treatment with methotrexate, benzodiazepines, opioids, or other centrally depressant drugs * Recent intraocular gas injection * Known impaired liver or kidney function * Pregnant or breastfeeding women (fertile women, defined as amenorrhea for less than 12 months, must have a negative hCG pregnancy test prior to receiving the study intervention)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07690358 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Intoxication by Drug. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07690358 currently recruiting?
Yes, NCT07690358 is actively recruiting participants. Contact the research team at cua@biomed.au.dk for enrollment information.
Where is the NCT07690358 trial being conducted?
This trial is being conducted at Aarhus, Denmark.
Who is sponsoring the NCT07690358 clinical trial?
NCT07690358 is sponsored by University of Aarhus. The trial plans to enroll 40 participants.