NCT07422441 Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair
| NCT ID | NCT07422441 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Swissmed Hospital |
| Condition | Hernia, Ventral |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2026-02-20 |
| Primary Completion | 2026-11-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 50 participants in total. It began in 2026-02-20 with a primary completion date of 2026-11-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
People undergoing repair of large ventral hernias can develop breathing problems after surgery, especially around the time when the abdominal wall is closed. During closure, pressure inside the abdomen may increase and lung mechanics can worsen. This study will evaluate a structured intraoperative decision approach that uses standard anesthesia measurements of static respiratory system compliance at predefined timepoints to support the choice of abdominal wall closure technique. The main goal is to assess the rate of early postoperative respiratory failure within 72 hours after surgery.
Eligibility Criteria
Inclusion Criteria: * Age 18 years or older * Elective repair of a large ventral abdominal wall hernia (including incisional hernia) * Preoperative botulinum toxin A preparation performed as part of the local prehabilitation pathway * Preoperative abdominal CT available * General anesthesia with mechanical ventilation and feasibility of standardized intraoperative respiratory mechanics measurements Exclusion Criteria: * Severe preoperative respiratory failure judged to preclude standardized intraoperative respiratory mechanics assessment * Inability to obtain reliable static respiratory system compliance measurements at predefined timepoints * Hemodynamic instability preventing protocolized measurements (as judged by the anesthesiologist)
Contact & Investigator
Irmina Anna Śmietański, MD, PhD
PRINCIPAL INVESTIGATOR
Śmietański Hernia Center, LUX MED Hospital in Gdańsk
Frequently Asked Questions
Who can join the NCT07422441 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Hernia, Ventral. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07422441 currently recruiting?
Yes, NCT07422441 is actively recruiting participants. Contact the research team at worldofsurge@gmail.com for enrollment information.
Where is the NCT07422441 trial being conducted?
This trial is being conducted at Gdansk, Poland.
Who is sponsoring the NCT07422441 clinical trial?
NCT07422441 is sponsored by Swissmed Hospital. The principal investigator is Irmina Anna Śmietański, MD, PhD at Śmietański Hernia Center, LUX MED Hospital in Gdańsk. The trial plans to enroll 50 participants.