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Recruiting NCT05202964

Compliance and Tolerance to Oral AntiBiotherapy in Osteoarticular Infections (OTABIO)

Trial Parameters

Condition Drug-Related Side Effects and Adverse Reactions
Sponsor Hospices Civils de Lyon
Study Type OBSERVATIONAL
Phase N/A
Enrollment 60
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2024-06-13
Completion 2026-09
Interventions
Tolerance and adherence to oral antibiotics in patients managed for BJI

Brief Summary

Bone and joint infections (BJI) are most often bacterial infections that can occur after surgery or de novo. They are rarely fatal in the short term, but are associated with significant morbidity, impaired quality of life and significant costs. Treatment of BJI is based on antibiotic therapy, often combined with surgery. Antibiotic therapy, at high doses, lasts a minimum of 6 weeks. It can be responsible for severe adverse effects. These characteristics (prolonged duration, multiple daily doses, and adverse effects) are known to negatively affect treatment adherence in general.

Eligibility Criteria

Inclusion Criteria: * ≥ 18 years * Diagnosis of osteoarticular infection * Treatment with at least one oral antibiotic for a minimum expected duration ≥ 6 weeks with an expected end of treatment date * Patient who was informed and did not object to participate in the study Exclusion Criteria: * Treatment for BJI with oral antibiotic without end of treatment date * treatment for BJI with parenteral antibiotic only * patient who doesn't have a telephone number or who doesn't want to give it * Adults subject to a legal protection measure * Pregnant or breastfeeding women

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