Comparison of the Immune Response to Natural COVID-19 Infection and Vaccination
This study compares how the body's immune system responds to COVID-19 infection versus COVID-19 vaccination. Researchers are investigating whether natural infection and vaccination produce similar or different immune responses to help understand protection against the virus.
Key Objective: This trial aims to determine whether vaccination provides comparable immune protection to natural COVID-19 infection.
Who to Consider: People who have had COVID-19, those who have been vaccinated, or those willing to be vaccinated should consider enrolling to help researchers understand immune responses.
Trial Parameters
Brief Summary
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic has been intensified by no population-based immunity to the severe acute respiratory disease coronavirus 2 (SARS-CoV2) and initially lack of effective treatments or vaccines available to mitigate the pandemic. Currently, two COVID-19 vaccines are available for vaccination in Europe through conditional marketing authorisation granted by the European Medicines Agency and further vaccine will be licensed. These vaccines have shown good vaccine efficacy in phase 3 vaccine trials. We will recruit subjects who will be prioritised for vaccination with the primary aim of comparing the immune responses after COVID-19 vaccination and natural SARS-CoV-2 infection. In Western Norway we have recruited cohorts of health care workers and patients infected with SARS-CoV-2 and will extend to COVID-19 vaccinees. Demographic, clinical data and repeated blood samples will be collected to evaluate the complications and kinetics, duration and breadth of the immune responses comparing natural infection to vaccination.
Eligibility Criteria
Inclusion Criteria: * subjects prioritized by national vaccination program Exclusion Criteria: * Children * unable or unwilling to provide informed consent