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Recruiting NCT07313839

Comparison of Self-Locking Versus Traditional Sutures in Double-Layer Laparoscopic Vaginal Vault Closure After Hysterectomy (BI-SURE Trial)

Trial Parameters

Condition Gynecologic Cancers
Sponsor Azienda Ospedaliero-Universitaria di Parma
Study Type INTERVENTIONAL
Phase N/A
Enrollment 310
Sex FEMALE
Min Age 18 Years
Max Age N/A
Start Date 2025-10-07
Completion 2027-01
Interventions
Double-Layer Vaginal Vault Closure with Self-Locking SutureDouble-Layer Vaginal Vault Closure with Polyglactin 910

Brief Summary

Vaginal vault closure after laparoscopic or robotic hysterectomy may be associated with postoperative complications such as vaginal cuff dehiscence, infection, and bleeding. The optimal suture material and technique for laparoscopic colporrhaphy, particularly in patients undergoing surgery for gynecologic malignancies, remain controversial. The BI-SURE trial is a multicenter, randomized controlled study designed to compare double-layer self-locking sutures versus double-layer traditional Polyglactin 910 sutures for laparoscopic vaginal vault closure after hysterectomy. The study aims to evaluate postoperative effectiveness and safety within three months after surgery.

Eligibility Criteria

Inclusion Criteria: * Patients undergoing laparoscopic or robotically assisted hysterectomy for gynecologic malignant disease * Age ≥ 18 years * Ability to provide written informed consent Exclusion Criteria: * Laparotomic or vaginal hysterectomy * Contraindication to laparoscopic vaginal vault closure

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