Comparison of Microglial Activation in Severe Asthma and Healthy Controls
Trial Parameters
Brief Summary
The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of 3 visits, participants will: * Complete questionnaires * Complete computer tasks * Undergo allergy skin test and breathing tests * Give two blood samples * Give a sputum sample * Complete brain imaging scans Researchers will compare results between participants with asthma, and participants who do not have asthma.
Eligibility Criteria
Inclusion Criteria: * Ability to understand and the willingness to sign a written informed consent document * Individuals with no health concerns that might affect the outcome of the study * Age 18-75 years of age * Ability to tolerate a simulated MRI brain scanning session * In the opinion of the investigator, capable and willing to grant written informed consent and cooperate with study procedures and requirements * High-affinity TSPO-binding genotype. Mixed (high/low) binding-affinity genotype may be included at PIs discretion * For participants with severe asthma: * Physician diagnosis of asthma for at least six months prior to screening (can be determined at the discretion of an asthma/allergy physician member of the study team) * Severe asthmatics must meet the ATS definition of severe asthma and/or be currently receiving a GINA Step 4 or 5 therapy or daily treatment of 320mcg budesonide. Therapy may include ongoing use of currently approved biologic immunomodulators Exclusion Cr