NCT06272461 Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
| NCT ID | NCT06272461 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Tunis El Manar |
| Condition | Colorectal (Colon or Rectal) Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 50 participants |
| Start Date | 2023-10-01 |
| Primary Completion | 2026-02-10 |
Trial Parameters
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Brief Summary
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
Eligibility Criteria
INCLUSION CRITERIA: * Patients aged 18 or older. * American society of anesthesiologists' (ASA) physical status of I-III. * Elective open colorectal surgery. NON INCLUSION CRITERIA: * Patients with contraindications to lidocaine or ketamine. * Corticosteroid therapy within the last 6 months. * History of immunosuppressive therapy. * History of surgery in the last 3 months. * Personal medical history of inflammatory bowel disease. * Personal medical history of cardiac arrythmias or conduction disorders. * Alcohol or drug abuse. * Chronic use of opioids or benzodiazepines. EXCLUSION CRITERIA: * Severe intraoperative complications. * Duration of surgery longer than 5 hours.
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