NCT05469984 Comparing Two Prophylactic Antibiotic Protocols in Women With Term Prolonged Pre-labor Rupture of Membrane and Preterm Labor
| NCT ID | NCT05469984 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Western Galilee Hospital-Nahariya |
| Condition | Preterm Labor With Preterm Delivery |
| Study Type | INTERVENTIONAL |
| Enrollment | 600 participants |
| Start Date | 2022-11-25 |
| Primary Completion | 2025-09-25 |
Trial Parameters
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Brief Summary
This randomized prospective trial aimed to compare 2 prophylactic antibiotic regiment (ampicillin alone versus ampicillin plus gentamycin) in term prolonged pre-labor rupture of membrane and in preterm deliveries and examine related obstetrical outcome and infectious morbidity
Eligibility Criteria
Inclusion Criteria: maternal age \> 18 years singleton pregnancy vertex presentation prolonged \>18 h prom or preterm delivery \- Exclusion Criteria: * GBS carrier * preterm premature rupture of membrane for conservative treatment * intra-uterine fetal death fetal major anomaly * drug allergy for the antibiotic in use in this study * women receiving antibiotic treatment for other infection such as urinary tract infection