NCT07544251 Comparing Sarecycline and Doxycycline Effects on the Skin and Gut Bacteria in Acne.
| NCT ID | NCT07544251 |
| Status | Recruiting |
| Phase | Phase 4 |
| Sponsor | Integrative Skin Science and Research |
| Condition | Acne Vulgaris |
| Study Type | INTERVENTIONAL |
| Enrollment | 30 participants |
| Start Date | 2026-04-20 |
| Primary Completion | 2027-04 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
This study is being done to help better understand how the gut and skin bacteria of the body change when people with acne are treated with Sarecycline or Doxycycline. The bacteria in the gut and on the skin will be studied to see how each treatment may affect them and whether they change the profile of the bacteria that is present.
Eligibility Criteria
Inclusion Criteria: 1\) Diagnosis of acne vulgaris with: * At least 10 inflammatory lesions (papules, pustules, and nodules) up to 100 noninflammatory lesions (open and closed comedones) * No more than 2 nodules on the face Exclusion Criteria: 1. Dermatological condition of face or facial hair that could interfere with clinical evaluations 2. Subjects who have used the following medications (topical refers only to the facial area) will not be eligible: 2a) Within 2 week prior to randomization: * Topical acne medications such as retinoids, antibiotics, hormonal modulators * Topical benzoyl peroxide * Topical anti-inflammatories and corticosteroids 2b) Within 4 weeks prior to randomization: * Systemic antibiotics * Systemic acne treatments * Oral probiotic supplement * Systemic corticosteroids 2c) Within 12 weeks prior to randomization: * Systemic retinoids 3\) Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study.