NCT07068204 Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)
| NCT ID | NCT07068204 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Dr. Joachim Enax |
| Condition | Caries, Dental |
| Study Type | INTERVENTIONAL |
| Enrollment | 164 participants |
| Start Date | 2026-01-22 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 164 participants in total. It began in 2026-01-22 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.
Eligibility Criteria
Inclusion Criteria: * A minimum of 10 healthy molars and premolars (DMFS of these teeth = 0) * Willingness to use an electric (powered) toothbrush * Willingness to use interdental floss * Willingness to have bitewing radiographs taken * Willingness to undergo an oral examination by an intraoral camera (DIAGNOcam) Exclusion Criteria: * Untreated caries \[clinical investigation and analysis with an intraoral camera (DIAGNOcam)\] (→ unsuitable subjects with one or two untreated caries in need of a restoration can become eligible after restorative therapy. If there are three or more untreated caries patients will be excluded) * Xerostomia (medication, radiation, disease induced) * Chemo/radiation therapy * Physical or mental disability which prevents proper oral health care * Orthodontic treatment * Severe periodontitis at the Baseline Visit (pocket depth on at least one tooth ≥ 5.5 mm) * Known hypersensitivity to one of the ingredients of the toothpastes to be tested * Regular medication intake interfering with salivary function or flow * Current pregnancy, the wish to become pregnant, the suspicion of being pregnant, or breastfeeding or in the course of the study * 3 or more carious lesions/restorations in last 36 months until Baseline Visit * Teeth missing due to caries in last 36 months until Baseline Visit
Contact & Investigator
Elzbieta Paszynska, Prof., DDS, Msc, PhD
PRINCIPAL INVESTIGATOR
Poznan University of Medical Sciences
Frequently Asked Questions
Who can join the NCT07068204 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 45 Years, studying Caries, Dental. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07068204 currently recruiting?
Yes, NCT07068204 is actively recruiting participants. Contact the research team at joachim.enax@drwolffgroup.com for enrollment information.
Where is the NCT07068204 trial being conducted?
This trial is being conducted at Bialystok, Poland, Poznan, Poland.
Who is sponsoring the NCT07068204 clinical trial?
NCT07068204 is sponsored by Dr. Joachim Enax. The principal investigator is Elzbieta Paszynska, Prof., DDS, Msc, PhD at Poznan University of Medical Sciences. The trial plans to enroll 164 participants.