NCT07467954 Comparative Effectiveness of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser in Skin Rejuvenation
| NCT ID | NCT07467954 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Universitas Padjadjaran |
| Condition | Skin Rejuvenation |
| Study Type | INTERVENTIONAL |
| Enrollment | 15 participants |
| Start Date | 2025-10-14 |
| Primary Completion | 2026-03-10 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 15 participants in total. It began in 2025-10-14 with a primary completion date of 2026-03-10.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis, including decreased collagen characterized by dermal thinning, as well as alterations in skin appearance such as laxity and wrinkles. Laser therapy is one of the treatment modalities for skin rejuvenation, aiming to induce neocollagenesis and collagen remodeling, resulting in dermal thickening and improvement in skin appearance. Fractional CO₂ laser is an ablative laser considered the gold standard therapy for skin rejuvenation, whereas Long Pulsed (LP) Nd:YAG 1064 nm is a nonablative laser that is also used for skin rejuvenation. To date, there have been no studies evaluating the comparative effectiveness between fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation. Therefore, research comparing the effectiveness of fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation is needed, assessed based on dermal thickness, skin elasticity, wrinkles, and Global Aesthetic Improvement Scale scores.
Eligibility Criteria
Inclusion Criteria: * Male and female patients with skin aging classified as Glogau scale II-III * Age 30-59 years. Exclusion Criteria: * Pregnant or breastfeeding women. * Active smokers. * Individuals with high levels of sun exposure. * History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months. * Use of oral isotretinoin within the past six months. * Use of topical retinoids or their derivatives, topical vitamin C, or other collagen-stimulating and skin-rejuvenating agents within the past two weeks. * Use of oral vitamin C, collagen-stimulating supplements, antioxidants, or hormone therapy with skin-rejuvenating effects within the past one month. * Presence of active facial skin inflammation. * History of keloid formation. * History of allergy to topical lidocaine anesthesia.
Contact & Investigator
Kartika Ruchiatan, M.D.
PRINCIPAL INVESTIGATOR
Faculty of Medicine Universitas Padjadjaran Bandung
Frequently Asked Questions
Who can join the NCT07467954 clinical trial?
This trial is open to participants of all sexes, aged 30 Years or older, up to 59 Years, studying Skin Rejuvenation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07467954 currently recruiting?
Yes, NCT07467954 is actively recruiting participants. Contact the research team at rizalbdg@gmail.com for enrollment information.
Where is the NCT07467954 trial being conducted?
This trial is being conducted at Bandung, Indonesia.
Who is sponsoring the NCT07467954 clinical trial?
NCT07467954 is sponsored by Universitas Padjadjaran. The principal investigator is Kartika Ruchiatan, M.D. at Faculty of Medicine Universitas Padjadjaran Bandung. The trial plans to enroll 15 participants.