Combined Blood Pressure Medication and Activity Scheduling for Low Mood
Trial Parameters
Brief Summary
This study explores the effects of 7-day losartan (50mg) versus placebo with brief behavioural activation on emotional processing in young volunteers low in positive mood
Eligibility Criteria
Inclusion Criteria: * Willing and able to provide informed consent * Aged 18-65 years * Self-reported low levels of positive mood * Sufficient written and spoken English skills to understand study procedures * Normal or corrected to normal vision and hearing * Access to a computer and reliable internet connection Exclusion Criteria: * Antidepressant treatment or medication in last three months * Currently receiving cognitive-behavioural therapy with behavioural activation * History of psychosis or bipolar disorder * History of substance dependence * Use of illegal drugs in last 3 months * First-degree relative with history of psychosis or bipolar disorder * Current or past hospitalisation for mental health reasons * BDI-II score \>30 * Judged to be currently at clinical risk of suicide * Past suicide attempt * CNS-medication last 6 weeks (including in another study) * Severely underweight or overweight in a manner that renders them unsuitable for the study in the opinion of the study m