NCT07663578 Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)
| NCT ID | NCT07663578 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, Davis |
| Condition | Epilepsy |
| Study Type | INTERVENTIONAL |
| Enrollment | 15 participants |
| Start Date | 2025-04-16 |
| Primary Completion | 2027-04-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 15 participants in total. It began in 2025-04-16 with a primary completion date of 2027-04-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to learn how a non-invasive brain stimulation method called Temporally Interfering Electric Fields Stimulation (TIEFS) affects brain activity and thinking in adults. TIEFS uses electrical currents applied to the scalp to influence brain activity without surgery. The main questions this study aims to answer are: * How does TIEFS change brain signals measured with brain recordings? * Does TIEFS affect thinking abilities such as memory, language, movement, or perception? * Is TIEFS safe and well tolerated when used in people? This study includes two groups of participants. One group includes adults with epilepsy who are already undergoing specialized brain monitoring as part of their medical care. The other group includes healthy adults with no history of seizures. Participants will: * Receive brief sessions of TIEFS using electrodes placed on the scalp * Complete computer-based tasks that test memory, attention, language, or movement. Answer questions about how the stimulation feels * Have brain activity recorded during the study Each study visit lasts up to three hours and may occur in one or two sessions. Information from this study may help researchers better understand the human brain and support the development of future non-invasive brain stimulation treatments.
Eligibility Criteria
Inclusion Criteria: * Adult patients (age 18-65 years of age) undergoing an intracerebral electrophysiology study for epilepsy pre-surgical evaluation are eligible for inclusion. * For healthy control subjects are also eligible for inclusion (Scalp EEG measurements). * Participants must be able to sufficiently speak and understand English or Spanish for consent and be able to understand and complete cognitive tasks. * All subjects must have the ability to give valid informed consent. Exclusion Criteria: * No pregnant women will be recruited. * People with implanted electrical devices such as Deep Brain Stimulation devices or Pacemakers. * No prisoners will be recruited.
Contact & Investigator
Nigel P Pedersen, MBBS
PRINCIPAL INVESTIGATOR
University of California Davis, School of Medicine, Neurology Department
Frequently Asked Questions
Who can join the NCT07663578 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Epilepsy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07663578 currently recruiting?
Yes, NCT07663578 is actively recruiting participants. Contact the research team at nppedersen@health.ucdavis.edu for enrollment information.
Where is the NCT07663578 trial being conducted?
This trial is being conducted at Sacramento, United States.
Who is sponsoring the NCT07663578 clinical trial?
NCT07663578 is sponsored by University of California, Davis. The principal investigator is Nigel P Pedersen, MBBS at University of California Davis, School of Medicine, Neurology Department. The trial plans to enroll 15 participants.
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