Trial Parameters
Brief Summary
CRiALS is an umbrella protocol through which people are recruited to participate in a range of research studies being conducted by the ALS Research Collaboration (ARC).
Eligibility Criteria
Inclusion Criteria: 1. At least 18 years of age. 2. Member of at least one of the following categories: 1. Individuals affected with ALS or a related neurodegenerative disease (sporadic or familial) 2. Unaffected individuals from fALS pedigrees, including pre-symptomatic individuals at genetic risk for ALS or individuals from pedigrees of ALS related diseases. 3. Healthy controls 3. Able and willing to comply with relevant procedures. Exclusion Criteria: 1\. Subject has a condition or is in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions (e.g., multiple sclerosis, neuropathy, myelopathy).